DISCO is a VUV to visible beamline dedicated to biochemistry, chemistry and cell biology. The spectral region is optimised between 60 and 700 nm with conservation of the natural polarization of the light.

Two endstations are operated around a common scientific topic : Biomolecular investigations, with special emphasis on proteins, particularly membrane proteins:

  • A circular dichroism endstation SR-O-CD in the VUV range which opens new fields in the investigation of biological molecules, with, in particular, the possibility to follow rapid kinetics such as proteins folding and unfolding in real time.
  • An imaging endstation for biological (living cells) and material applications with new possibilities of excitation and detection, also allowing biomedical investigation of normal and tumoral tissues moreover, new paradigms in autofluorescence diagnosis appear and "abandonned" molecules that fluoresce only in the UV can be used as probes.
Beamline Energy Range
1 - 10 [eV]
Spot Size On Sample Hor
0.2 - 4000 [um]
Spot Size On Sample Vert
0.2 - 4000 [um]
Endstations or Setup

Imaging

Microscopes
- TELEMOS : Full Field Axioobserver Z1 with PI YZ stage
- POLYPHEME : Inverted microspectrofluorimeter
Spectrometer
iHR320 excitation monochromator

Sample

Sample Type
Liquid

SRCD

Spectrometer
Circular dichroism spectrometer

Sample

Sample Type
Liquid
contacts
JAMME Frederic
WIEN Frank
CHAUVET HUGO
Techniques
Absorption
  • Time-resolved studies
  • UVCD
Imaging
  • Fluorescence imaging
  • Medical application
Disciplines
Chemistry
  • Biochemistry
  • Green Chemistry
  • Physical Chemistry
Earth Sciences & Environment
  • Ecosystems & Biodiversity
  • Geology
  • Global change & Climate observation
  • Marine science/Oceanography
  • Mineralogy
  • Plant science
  • Technique Development - Earth Sciences & Environment
Engineering & Technology
  • Nanotechnology & production processes
Humanities
  • Arts
  • Cultural Heritage
  • Technique Development - Humanities
Life Sciences & Biotech
  • Agriculture & Fisheries
  • Biophysics
  • Evolutionary science
  • Food quality and safety
  • Medicine
  • Molecular and cellular biology
  • Other - Life Sciences & Biotech
  • Pharmaceutics (drug screening)
  • Protein and macromolecular structures
  • Technique Development - Life Sciences & Biotech
Material Sciences
  • Knowledge based multifunctional materials
Mathematics
  • Numerical analysis
Physics
  • Nanophysics & physics of confined matter
  • Optics
control/Data analysis
Control Software Type
  • Igor, MicroManager
Data Output Type
  • images, spectra, spectral images, temp
Data Output Format
  • tif, igor, ascii
Softwares For Data Analysis
  • FIJI, Igor, ImageJ, Huygens, CiDiPy